International Journal of Clinical Research

Objective: Analysis of ultrasound-guided puncture biopsy combined with contrast-enhanced ultrasound in the diagnosis of benign and malignant thyroid nodules. Methods: 70 patients who underwent thyroid nodulectomy in our hospital between January 2023 and January 2024 were selected. All patients underwent ultrasound-guided puncture biopsy, contrast-enhanced ultrasound examination, and combined examination before surgery, with the intraoperative rapid pathological section diagnosis result as the gold standard. Compare and evaluate the sensitivity, specificity, and accuracy of ultrasound-guided puncture biopsy, contrast-enhanced ultrasound examination, and combined examination. Meanwhile, analyze the ultrasound manifestations of benign and malignant nodules. Results: Out of 70 patients, a total of 74 thyroid nodules were found, including 23 malignant (25 nodules) and 47 benign (49 nodules). Ultrasound guided biopsy detected 52 positive and 22 negative cases; Ultrasound contrast imaging detected 46 positive and 28 negative cases. The combined application diagnosed 50 good and 24 evil cases, with a sensitivity of 96%, specificity of 100%, and accuracy of 98.65%. These indicators were superior to using ultrasound-guided biopsy alone (92%, 97.96%, 97.30%) or contrast-enhanced ultrasound alone (84%, 85.74%, 85.14%) with statistical significance (P<0.05), but there was no significant difference compared to using biopsy alone (P>0.05). Conclusion: The implementation of ultrasound-guided puncture biopsy combined with contrast-enhanced ultrasound detection in the diagnosis of benign and malignant thyroid nodules has achieved significant results, which can significantly improve diagnostic efficiency. Has high application value.

Ultrasound guided puncture biopsy; Contrast-enhanced ultrasound; Thyroid nodules; Diagnosis of benign and malignant tumors