相关学者
相关机构
刺梨活性成分调节糖代谢机制的研究进展
Advances in the mechanism of sugar metabolism regulated by active constituents of Rosa roxburghii
ES评分9.25
| DOI | 10.12208/j.ijcr.20250234 |
| 刊名 |
International Journal of Clinical Research
|
| 年，卷(期) | 2025, 9(5) |
| 作者 |
|
| 作者单位 |
1 河北大学护理学院 河北保定,2 河北大学附属医院 河北保定 |
| 摘要 |
糖尿病现已经成为世界各地突出的公共卫生问题，发病风险较高，可引发多种并发症。刺梨是我国西南地区广泛种植的重要植物资源，也是我国传统的食药用植物，因其营养价值高、保健功能强而深受消费者青睐。多糖、多酚、三萜类等成分是刺梨中的主要天然活性成分，具有多种生理活性和药用价值，并表现出显著的抗糖尿病作用。本文综述了刺梨中主要活性成分在降低血糖，以及调节血脂、抗氧化、改善炎症状态等糖尿病并发症中的有效作用，探讨了这些活性成分在糖尿病发病机制中的代谢机理，进一步阐明了刺梨调节血糖的作用机制。
|
| Abstract |
Diabetes has become a prominent public health problem around the world, with a high risk of onset and multiple complications. Rosa roxburghii is an important plant resource widely planted in southwest China, and is also a traditional edible and medicinal plant in China. Highly favored by consumers due to its nutritional value and powerful health benefits, as well as its high cost-effectiveness. Polysaccharides, polyphenols and triterpenoids are the main natural active components in Rosa roxburghii, which have many physiological activities and medicinal values, and show significant anti-diabetic effects. This paper reviewed the effective effects of the main active components in Rosa roxburghii on lowering blood glucose, regulating blood lipid, antioxidation and improving inflammatory state of diabetes mellitus, discussed the metabolic mechanism of these active components in the pathogenesis of diabetes mellitus, and further clarifies the mechanism of Rosa roxburghii regulating blood glucose.
|
| 关键词 |
刺梨；活性成分；2型糖尿病；糖代谢机制
|
| KeyWord |
Rosa roxburghii; Active components; Type 2 diabetes mellitus; Mechanism of glucose metabolism
|
| 基金项目 | |
| 页码 | 53-57 |
- 参考文献
- 相关文献
[1] LI H, FANG W, WANG Z, et al. Physicochemical, biological properties, and flavour profile of Rosa roxburghii Tratt, Pyracantha fortuneana,and Rosa laevigata Michx fruits: A comprehensive review
[J]. Food chemistry, 2022, 366:130509.
[2] YIN C, ZHANG Y, ZHANG L, et al. Exploring Rosa roxburghii Tratt polysaccharides: From extraction to application potential in functional products - An in-depth review
[J]. Int J Biol Macromol, 2024, 280:135543.
[3] JAIN A, SARSAIYA S, GONG Q, et al. Chemical diversity, traditional uses, and bioactivities of Rosa roxburghii Tratt: A comprehensive review
[J]. Pharmacol Ther, 2024, 259:108657.
[4] 陈珍,任廷远,谭书明.黔产不同海拔野生型刺梨原汁对2型糖尿病小鼠糖脂代谢及氧化应激的干预作用
[J].现代食品科技,2022, 38(09):60-70.
[5] 谭芸芸.刺梨鞣花酸对2型糖尿病的调控作用
[D].贵州大学, 2023.
[6] WANG L, WEI T, ZHENG L, et al. Recent Advances on Main Active Ingredients, Pharmacological Activities of Rosa roxbughii and Its Development and Utilization
[J]. Foods, 2023,12(5):1051-1051.
[7] ZHANG S, XIANG J L, LONG X X, et al. Anti-Inflammatory and α-Glucosidase Inhibitory Triterpenoid with Diverse Carbon Skeletons from the Fruits of Rosa roxburghii
[J]. Journal of agricultural and food chemistry,2024,72(20): 11503-11514.
[8] CHEN C, TAN S, REN T,et al. Polyphenol from Rosaroxburghii Tratt Fruit Ameliorates the Symptoms of Diabetes by Activating the P13K/AKT Insulin Pathway in db/db Mice
[J]. Foods, 2022, 11(5):636.
[9] 汪磊.刺梨多糖的分离纯化、降血糖作用及其对肠道微生态的影响
[D].华南理工大学,2019.
[10] SINGH J, POOJA , KUMAR P, et al. Impact of probiotics in alleviating type 2 diabetes risk in clinical trials: A meta-analysis study
[J].Human Gene, 2023, 35.
[11] WANG G Q, LIU J, XIA Y J, et al. Probiotics-based interventions for diabetes mellitus: A review
[J].Food Bioscience, 2021, 43.
[12] WANG H, CHEN Z, WANG M, et al. The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice
[J].Foods, 2022, 11(12):1747-1747.
[13] LUO Y, TANG R, QIU H, et al. Widely targeted metabolomics-based analysis of the impact of L. plantarum and L. paracasei fermentation on rosa roxburghii Tratt juice
[J].International journal of food microbiology, 2024, 417:110686-110686.
[14] JI J C, ZHANG S, TANG L, et al. Integrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice
[J].Journal of Functional Foods, 2022, 90:104978.
[15] SARA N, PEDRO V, PEDRO G, et al. Blueberry as an Attractive Functional Fruit to Prevent (Pre) Diabetes Progression
[J].Antioxidants, 2021, 10(8):1162-1162.
[16] YAN G Y, ZHENG P Y, WENG S Q,et al. Comparison of Chemical Compositions and Antioxidant Activities of Fresh and Dried Rosa roxburghii Tratt Fruit
[J].Natural Product Communications, 2022, 17(4).
[17] 伍勇,韦艾骥,杨堃,等.刺梨多糖提取物对小鼠Ⅱ型糖尿病的干预研究
[J].广西植物, 2023, 43(11):2120-2130.
[18] JIN Y, LI Y, WANG L, Fu X, Li C. Physicochemical characterization of a polysaccharide from Rosa roxburghii Tratt fruit and its antitumor activity by activating ROS mediated pathways
[J].Current Research in Food Science, 2022, 51581-1589.
[19] 陈超.刺梨多酚黄酮类物质分离纯化、降血糖活性及机理研究
[D]. 贵州大学, 2022.
[20] XU S J, WANG X, WANG T Y, et al. Flavonoids from Rosaroxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo
[J]. Aging-US. 2020, 12(16):16368-16389.
[21] XU S J, ZHANG F, WANG L J, et al. Flavonoids of Rosa roxburghii Tratt offers protection against radiation induced apoptosis and inflammation in mouse thymus
[J]. Apoptosis, 2018, 23:470-483.
[22] SHARMA P, HAJAM YA, KUMAR R, et al.Complementary and alternative medicine for the treatment of diabetes and associated complications: A review on therapeutic role of polyphenols
[J].Phytomedicine Plus, 2022, 2(1):100188.
展开
展开
展开
展开