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热门期刊: 细胞研究(英文版)中华医学杂志(英文版)国际临床研究杂志

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吸烟行为对男性慢性精神分裂症患者临床结局的影响分析

The Studying of Clinical Outcomes of Smoking Behavior in the Male Patients with Chronic Schizophrenia

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2016, 43(4)
作者
作者单位

上海交通大学医学院附属精神卫生中心临床十一科 ;
上海交通大学医学院附属精神卫生中心康复科 ;
上海交通大学医学院附属精神卫生中心 ;
上海交通大学医学院附属精神卫生中心 ;

摘要
琚明亮 刘燕 陈文忠 潘晓鸥 【摘要】目的:探讨吸烟行为对男性慢性精神分裂症患者的临床结局的影响。方法:选取在我院接受长期住院治疗的男性慢性精神分裂症患者95例,根据患者是否吸烟,将这95例患者分为吸烟组(n=65)和非吸烟组(n=30)。使用住院护士观察量表(NOSIE)评价患者的精神状况和日常状况,采用连续作业测验(CPT)对患者进行测试,评价两组患者的认知功能。采用阳性和阴性症状量表评价两组患者的精神症状。结果:NOSIE量表结果显示,吸烟组患者的社会能力、社会兴趣、总积极因子和总分显著高于对照组(P<0.05),吸烟组患者的精神病因子、迟缓因子、总消极因子显著低于非吸烟组患者(P<0.05),根据尼古丁依赖系数,进一步将吸烟组患者分为重度尼古丁依赖组和轻度尼古丁依赖组,CPT测验结果表明,重度尼古丁依赖组患者的CPT正确反应数显著高于轻度尼古丁依赖组和非吸烟组(P<0.05),而轻度尼古丁依赖组和非吸烟组患者的CPT正确反应系数差异无统计学意义(P>0.05)。吸烟组患者的PANSS总分和阴性症状量表评分显著低于非吸烟组患者(P<0.05)。结论:吸烟是一种会给人体健康带来多种危害的行为,但是可能对慢性精神分裂症患者的认知功能和精神分裂症状可能具有一定的改善作用。
【Abstract】Objective: To explore the influence of clinical outcomes of smoking behavior in the male patients with chronic schizophrenia. Methods: 95 cases of patients with chronic schizophrenia were selected, according to whether patients with smoking, the 95 patients were divided into smoking group (n = 65) and non smoking group (n = 30).Use in hospital nurses observation scale (NOSIE) evaluation of the patients mental condition and daily status, By using positive and negative symptoms scale (positive and negative symptoms scale, PANSS) evaluation of two groups of patients mental symptoms. Results: Smoking NOSIE scale, according to the results of the group of patients with social ability, social interest, always positive factor and total score is significantly higher than control group (P < 0.05), a group of patients with smoking mental factor, slow factor, total negative factor significantly lower than non-smoking patients (P < 0.05), CPT test results show that the group of patients with severe nicotine dependence CPT reflect the number is significantly higher than mild nicotine dependence group and non smoking group (P < 0.05), and patients with mild nicotine dependence group and non smoking group of CPT correct response difference coefficient of no statistical significance (P > 0.05). Smoking group of patients with total scores of PANSS and negative symptoms scale score was significantly lower than non-smoking patients (P < 0.05). Conclusion: Smoking is a kind of behavior can bring a variety of hazards to human health, but there is a risk of cognitive function in patients with chronic schizophrenia and symptoms of schizophrenia may have certain effect.
关键词
【关键词】吸烟;慢性精神分裂症;临床结局
【Keywords】Smoking; Chronic schizophrenia; Clinical outcomes
基金项目
页码 620-622
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