Effect of Antidepressants on the post- Stroke depression
Journal of International Psychiatry
【摘要】：探讨急性脑卒中后抑郁的抗抑郁药物治疗对卒中预后的影响；方法 观察375例急性缺血性脑卒中患者，将60例卒中后抑郁患者随机分为研究组和对照组，两组均给予标准治疗及心理辅导，另外研究组加用帕罗西汀，观察神经功能损伤，抑郁状况等情况。结果 研究组治疗后4周和8周NIHSS和HAMD评分均较治疗前显著降低，有统计学差异，研究组与对照组之间亦有显著差异（P<0.05）。 结论 卒中后抑郁患者给予帕罗西汀抗抑郁治疗可显著改善预后。
【Abstract】Objective To study the effect of antidepressants on the acute post- Stroke depression (PSD) patients. Methods A total of 375 patients were studied. There were 60 PSD patients entered a double-blind randomized study of the efficacy of antidepressants to treat depressive disorders after stroke. Patients were assigned to either Paroxetine or placo. They were all assigned standard treatment for acute ischemia Stroke. Results Compared with the control group there were the lower NIHSS score and HAMD scores in observation group up 4 week and 8 weeks after treatment which was significant difference. Conclusion PSD patients treated with antidepressants had better recovery from disability post stroke.
【Keywords】Stroke， Depression， Paroxetine