Journal of International Psychiatry

Abstract: Objective: To investigate the clinical effect of ginkgo biloba extract united with fluoxetine on acute depression after cerebral infarction patients. Methods: 130 acute depression after cerebral infarction patients were randomly divided into observation group and control group, each group had 65 patients. The control group was given fluoxetine only, 20mg every morning, while the observation group was treated with ginkgol biloba extract and fluoxetine. Hamilton depression scale (HAMD) was applied to evaluating the curative effect. Results: Before treatment, HAMD scores of two group patients had no significant different (P>0.05); 4 weeks after treatment, six weeks after treatment, and 8 weeks after treatment, the observation group patients’ HAMD score was significantly lower than the control group, the scores were significant different (P<0.05); Clinical effects of two group patients were collected and analyzed, we found that, the observation group and control group patients’ total effective rates were 81.54% and 66.15%, respectively. The total effective rate of observation group was obviously higher than control group, the difference reached significant level (P<0.05). Conclusion: The clinical effect of ginkgo biloba extract united with fluoxetine on acute depression after cerebral infarction patients was remarkable, and it was more effective than only using fluoxetine, it is worth to popularized and used in clinical practice.

【Keywords】: Acute Cerebral Infarction; Depression; Ginkgol Biloba Extract; Fluoxetine;