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热门期刊: 细胞研究(英文版)中华医学杂志(英文版)国际临床研究杂志

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银杏提取物联合氟西汀治疗急性脑梗塞后抑郁的疗效评估

Therapeutic Effect Evaluation of Ginkgo Biloba Extract United with Fluoxetine on Acute Cerebral Infarction Depression,

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2016, 43(3)
作者
作者单位

陕西省咸阳市延安大学咸阳医院 ;
陕西省咸阳市延安大学咸阳医院 ;
陕西省咸阳市延安大学咸阳医院 ;
陕西省咸阳市延安大学咸阳医院 ;
陕西省西安市西安医学院第二附属医院 ;

摘要
【摘要】目的:探讨银杏提取物联合氟西汀治疗急性脑梗塞后抑郁的临床疗效。方法:130例急性脑梗塞后抑郁的患者被随机分为观察组和对照组,每组65例;对照组患者仅服用氟西汀,每日20mg,每日1次,晨服;观察组在对照组治疗的基础上,采用银杏提取物对患者进行治疗。使用汉密尔顿抑郁量表(HAMD)来评价疗效。结果:治疗前两组患者的HAMD评分无显著性差异(P>0.05);治疗后4周、治疗后6周和治疗后8周,观察组患者的HAMD评分明显低于对照组,两组间评分比较显著性差异(P<0.05);对两组患者的临床疗效进行统计分析,发现观察组和对照组的总有效率分别为81.54%和66.15%,观察组的总有效率明显高于对照组,两组间总有效率差异显著(P<0.05)。结论:银杏提取物联合氟西汀治疗急性脑梗塞后抑郁的作用显著,效果明显优于单一使用氟西汀的治疗疗效,值得在临床上推广应用。
Abstract: Objective: To investigate the clinical effect of ginkgo biloba extract united with fluoxetine on acute depression after cerebral infarction patients. Methods: 130 acute depression after cerebral infarction patients were randomly divided into observation group and control group, each group had 65 patients. The control group was given fluoxetine only, 20mg every morning, while the observation group was treated with ginkgol biloba extract and fluoxetine. Hamilton depression scale (HAMD) was applied to evaluating the curative effect. Results: Before treatment, HAMD scores of two group patients had no significant different (P>0.05); 4 weeks after treatment, six weeks after treatment, and 8 weeks after treatment, the observation group patients’ HAMD score was significantly lower than the control group, the scores were significant different (P<0.05); Clinical effects of two group patients were collected and analyzed, we found that, the observation group and control group patients’ total effective rates were 81.54% and 66.15%, respectively. The total effective rate of observation group was obviously higher than control group, the difference reached significant level (P<0.05). Conclusion: The clinical effect of ginkgo biloba extract united with fluoxetine on acute depression after cerebral infarction patients was remarkable, and it was more effective than only using fluoxetine, it is worth to popularized and used in clinical practice.
关键词
【关键词】急性脑梗塞;抑郁;银杏提取物;氟西汀
【Keywords】: Acute Cerebral Infarction; Depression; Ginkgol Biloba Extract; Fluoxetine;
基金项目
页码 474-476
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