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热门期刊: 细胞研究(英文版)中华医学杂志(英文版)国际临床研究杂志

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皮质下缺血性脑血管病患者额叶白质病变对认知领域的损害研究

The research of rationship between frontal white matter lesions and the damage of cognitive function in Subcortical ischemic cerebrovascular disease

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2016, 43(4)
作者
作者单位

商洛市中心医院神经内科 ;
商洛市中心医院神经内科 ;

摘要
【摘要】目的:探讨皮质下缺血性血管病患者额叶白质病变对认知功能的影响。方法:回顾性收集2013年1月至2015年1月期间我科住院诊断为皮质下缺血性脑血管病患者121例,根据额叶白质病变程度,将皮质下缺血性脑血管病患者分为轻度(67例)和重度(54例)脑白质病变组。同时选择同年龄段60例健康、无认知障碍者为对照组;所有受试者均为右利手,且母语均为中文。对三组受试者进行神经心理量表测定,评估其认知功能、记忆功能及执行功能,并对额叶白质病变的程度与认知功能进行非参数等级相关分析。结果:与轻度脑白质病变组和对照组相比,重度脑白质病变组的MMSE评分、AVLT评分、ROCF评分及Stroop评分明显降低,P值均<0.05。患者MMSE评分与脑白质病变损害严重程度呈正相关(R=0.933,P=0.013),即脑白质病变的严重程度与认知障碍程度呈正相关。结论:皮质下缺血性脑血管病患者,额叶的脑白质主要累及认知功能、记忆功能及执行功能,且脑白质病变的严重程度与认知障碍程度呈正相关。
[Abstract]Objective: to analysis effects on cognitive function with frontal lobe white matter lesions in subcortical ischemic vascular disease. Methods: retrospectively collected during the subcortical ischemic cerebrovascular disease 121 cases from January 2013 to January 2015, in our department. Divided them into two groups: mild (67 cases) and severe cerebral white matter lesions group (54 cases) according to the degree of frontal white matter lesions. Choose 60 cases the same age who are healthy and without cognitive impairment as the control group. All the subjects are right-handed, and the native language is Chinese. Evaluate the three groups with neuropsychological scale determination, and assess their cognitive function, memory function and executive function, and to find out the relationship of extent of the frontal lobe white matter lesions and cognitive function ues nonparametric rank correlation analysis.Results: compared with mild cerebral white matter lesions group and the control group, in severe brain white matter lesions group, the the MMSE scores, AVLT, ROCF and Stroop scoress are significantly lower,P values <0.05. MMSE scores and pathological changes of cerebral white matter damage in patients with severe degree were positively correlated (R = 0.933, P = 0.933), in other words, the severity of cerebral white matter lesions was positively correlated with the degree of cognitive impairment. Conclusion:1. subcortical ischemic cerebrovascular disease with mainly involving the frontal lobes of the brain white matter, and will lead to the disorder in memory function and executive function, cognitive function;2.the severity of cerebral white matter lesions was positively correlated with the degree of cognitive impairment.
关键词
【关键词】皮质下缺血性血管病;额叶白质病变;认知功能
[key words] subcortical ischemic vascular disease;The frontal white matter lesions;Cognitive function
基金项目
页码 597-600
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