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米氮平联合常规药物对慢性心力衰竭伴抑郁患者的疗效评价
Efficacy evaluation of mirtazapine combined with conventional medicine in patients with chronic heart failure and depression.
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DOI | |
刊名 |
Journal of International Psychiatry
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年,卷(期) | 2016, 43(3) |
作者 |
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作者单位 |
陕西省榆林市第一医院药剂科 ; |
摘要 |
【摘要】目的:探讨米氮平联合常规药物治疗慢性心力衰竭伴抑郁患者的疗效。方法:选取2014年1月至2015年4月我院收治的老年慢性心力衰竭合并抑郁的患者120例,随机分成米氮平组及对照组,对照组患者采用慢性心力衰竭常规药物治疗,米氮平组患者采用慢性心力衰竭常规药物治疗联合米氮平治疗,对比两组患者治疗前后的汉密尔顿抑郁量表评分及心功能。结果:与治疗前相比,两组患者治疗后30天、90天、180天、300天汉密尔顿抑郁量表评分较低;与对照组相比,米氮平组治疗后30天、90天、180天、300天汉密尔顿抑郁量表评分较低、评分差率较高,(p<0.05)。与治疗前相比,两组患者治疗后左室射血分数、左室短轴缩短率较高,6min步行试验距离较长,心率较慢(p<0.05);与对照组相比,米氮平组治疗后左室射血分数、左室短轴缩短率较高,6min步行试验距离较长,心率较慢(p<0.05)。结论:米氮平联合常规药物治疗慢性心力衰竭伴抑郁患者的疗效佳,可广泛应用。
【Abstract】 objectiveTo explore the efficacy of mirtazapine combined with conventional medicine in patients with chronic heart failure and depression.Method120 elderly patients with chronic heart failure and depression in our hospital from January 2014 to April 2015 were randomly divided into mirtazapine group and control group. Patients in control group were treated by conventional drug therapy for chronic heart failure while patients inmirtazapine groupwere treated bymirtazapine combined with conventional medicine. Hamilton Depression Scale score and cardiac function of patients in two groups before and after treatment were compared.ResultCompared to patientsbeforetreatment, patients inmirtazapine group and control group had lower Hamilton Depression Scale score 30, 90, 180, 300 days after treatment. Compared tocontrol group, patients in mirtazapine grouphad lower Hamilton Depression Scale score and higher score difference rate (p<0.05). Compared to patients before treatment, patients in mirtazapine group and control group had higher left ventricular ejection fraction and left ventricular fractional shortening, longer 6min walking test and slower heart rate (p<0.05). Compared to control group, patients in mirtazapine grouphadhigher left ventricular ejection fraction and left ventricular fractional shortening, longer 6min walking test and slower heart rate (p<0.05).Conclusion The efficacy of mirtazapine combined with conventional medicine in patients with chronic heart failure and depression is good and it can be widely used.
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关键词 |
【关键词】米氮平;慢性心力衰竭;抑郁;心功能;汉密尔顿抑郁量表评分
【Key word】Mirtazapine;Chronic heart failure;Depression;heart function;Hamilton Depression Scale score
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基金项目 | |
页码 | 458-460 |