热门期刊: 细胞研究(英文版)、 中华医学杂志(英文版)、国际临床研究杂志 等
棕榈酸帕利哌酮长效针剂对精神分裂症急性期及维持期心理社会功能影响
Effect of paliperidone palmitate long-acting injection on psychosocial function in acute and maintenance stage of schizophrenia
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DOI | |
刊名 |
Journal of International Psychiatry
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年,卷(期) | 2022, 49(3) |
作者 |
卢瑞玲*,
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作者单位 |
新乡市精神病医院精二科 ; |
摘要 |
[摘要] 目的:探讨精神分裂症患者治疗中使用棕榈酸帕利哌酮长效针剂的价值。方法:纳入80例精神分裂症患者研究(2020年1月~2021年4月),按双盲法分为对照组(n=40,采用利培酮治疗)、观察组(n=40,采用棕榈酸帕利哌酮长效针剂治疗),统计两组临床疗效、不良反应、临床症状评分、心理社会功能。结果:(1)临床疗效:观察组(95.00%)高于对照组(80.00%),组间对比P<0.05。(2)不良反应:观察组(1.24±1.05)分低于对照组(2.87±1.41)分,组间对比P<0.05。(3)临床症状评分:观察组治疗后3月、6月、12月观察组阳性、阴性、PANSS评分低于对照组,组间对比P<0.05。(4)心理社会功能:治疗前、急性期PSP评分对比无差异,维持期观察组PSP评分高于对照组,组间对比P<0.05。结论:棕榈酸帕利哌酮长效针剂在精神分裂症治疗中效果确切,可改善其临床症状及心理社会功能,亦可确保治疗安全性,值得借鉴及参考。
[Abstract] Objective: To explore the value of palmitate piperazone long-term injection in the treatment of schizophrenia. Methods: 80 schizophrenics patients were included in the study (January 2020 ~ April 2021), and divided into control group (n=40, risperidone treatment), observation group (n=40, palmitate palipezone long-term injection), and statistical analysis of the clinical efficacy, adverse reactions, clinical symptom score and psychosocial function of the two groups. Results: (1) the clinical effect: the observation group (95.00%) was higher than the control group (80.00%), and the comparison between the groups was P<0.05. (2) Adverse reactions: observation group (1.24 ± 1.05) lower than that of control group (2.87) ± The results showed that the difference between the groups was P<0.05. (3) Clinical symptom score: the observation group was positive, negative and PANSS score was lower than that of the control group in March, June and December after treatment, and the comparison between the groups was P< 0.05. (4) Psychosocial function: there was no difference in the score of PSP before treatment and acute stage, and the score of PSP in observation group was higher than that of control group in maintenance period, and P < 0.05. Conclusion: Palmitate piperazone long-term injection has a definite effect in the treatment of schizophrenia, can improve its clinical symptoms and psychosocial function, and ensure the safety of treatment, which is worth reference and reference.
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关键词 |
关键词:棕榈酸帕利哌酮长效针剂;精神分裂症;急性期;维持期;心理社会功能
Keywords: palmitic acid and piperazone long-term injection; Schizophrenia; Acute stage; Maintenance period; Psychosocial function
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基金项目 | |
页码 | 440-443 |