PD-1抑制剂治疗致免疫检查点抑制剂相关性肺炎1例并文献复习-国际临床研究杂志-科技核心数据库

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PD-1抑制剂治疗致免疫检查点抑制剂相关性肺炎1例并文献复习

Immune checkpoint inhibitor-related pneumonitis induced by PD-1 inhibitor: a case report and review of literature

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DOI	10.12208/j.ijcr.20220019
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(1)
作者	刘姚,王小溶,蒋南川,马万里,张建初*,
作者单位	华中科技大学同济医学院附属协和医院呼吸与危重症医学科湖北武汉 ; 华中科技大学同济医学院附属协和医院放射科湖北武汉 ;
摘要	免疫检查点抑制剂是癌症的新型有效治疗手段，但也带来了免疫相关不良事件，其中肺炎为在为常见的不良反应之一。我们报道一例肺鳞状细胞癌患者在使用PD-1抑制剂治疗后免出现疫检查点抑制剂相关性肺炎（CTCAE 2级）的病例，其肺CT主要表现为细支气管炎、机化性肺炎及肺肿块，肺活检病理示间质增生纤维化伴淋巴细胞浸润，同时我们文献回顾免疫抑制剂相关性肺炎的临床特征，影像学特征，病理学及治疗原则。 Immune checkpoint inhibitors are novel and effective treatments for cancer, but they also bring immune-related adverse events, of which pneumonia is one of the commonadversereactions. We report a case of immune checkpoint inhibitors-related pneumonitis (CTCAE 2) in a patient with lung squamous cell cancer treated with PD-1 inhibitor, in which lung computed tomography mainly showed bronchiolitis, organizing pneumonia and pulmonary mass-like lesions, and lung biopsy pathology showed interstitial fibroplasia with lymphocyte infiltration.Meanwhile, we reviewed literatures to describe the clinical features, imaging features, pathology and treatment for immune checkpoint inhibitors-related pneumonitis.
关键词	免疫检查点抑制剂；免疫相关性不良事件；肺炎；胸部CT；病理学 Immune Checkpoint Inhibitors; Immune-Related Adverse Events; Pneumonia; Chest CT Image; Pathology
基金项目
页码	147-153

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