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T细胞受体基因转导及应用的研究进展
Research progress of T cell receptor gene transduction and application
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| DOI | 10.12208/j.ijgf.20220003 |
| 刊名 |
International Journal of Genetics Frontiers
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| 年，卷(期) | 2022, 3(1) |
| 作者 |
张震*,
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| 作者单位 |
四川大学 四川成都 ; |
| 摘要 |
在近年来的相关研究调查中发现，针对退性抗原的过继性免疫治疗，针对包括肿瘤在内的许多疾病进行治疗时，都能够获得相对来说较为有效的效果，这也是一种临床上具有潜力和应用价值的新型治疗方式。T细胞识别抗原所形成的特异性与T细胞受体有极为密切的关联T细胞受体基因转导对于现代化的肿瘤过继免疫治疗提供了新的思路，通过转到某些疾病相关的抗原反应性T细胞克隆，T细胞受体基因能够使人外周血淋巴细胞形成对应的相关性抗原，在对患者进行临床治疗时获得了一定的效果，并且为研究人员提供了新的治疗思路。本文中针对T细胞、受体基因转导与应用作出了相应的研究，并针对 T细胞基因受体转导技术进行了分析，旨在为T细胞受体基因转导技术的应用提供帮助与参考。
In recent years, relevant research investigations have found that adoptive immunotherapy targeting degenerated antigens can achieve relatively effective results when treating many diseases including tumors, which is also a clinical A new type of treatment with potential and application value. The specificity formed by T cells recognizing antigens is closely related to T cell receptors T cell receptor gene transduction provides a new idea for modern adoptive immunotherapy of tumors, by transferring certain disease-related antigen reactivity T cell clones, T cell receptor genes can make human peripheral blood lymphocytes form corresponding related antigens, and have achieved certain results in clinical treatment of patients, and have provided researchers with new treatment ideas. In this paper, the corresponding research on T cell, receptor gene transduction and application is made, and the technology of T cell gene receptor transduction is analyzed, aiming to provide help and reference for the application of T cell receptor gene transduction technology .
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| 关键词 |
T细胞受体；基因转导技术；研究分析；免疫治疗
T cell receptor; gene transduction technology; research analysis; immunotherapy
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| 基金项目 | |
| 页码 | 7-9 |